Although Photoshop can give you some customized results with smart sharpen and unsharp mask filters used on layers with opacity sliders and masks to tweak the results other plug ins or programs may be more to your liking. I was underwhelmed by the first Topaz sharpening program but their current Sharpen Ai can produce some incredible results. I too use NIK at times. Currently for images beyond LR, especially higher iso Fuji images, I use Capture One 20 for my initial Noise Reduction and Sharpening, then back to LR. Then if I am having some problems, I will use Sharpen Ai.