Those setting reverting each time – somebody ought to hung by the thumbnails for that.
I’ve found the best results using DeNoise as the first step in PS – let it choose the method on Auto – I always seem to get Low Light and I find it amazing. I almost always let it do whatever sharpening the slider shows underneath the noise slider. The Clear algorithm is an old one and as of recently was not nearly as good – one of those “legacy” things?? Best to compare all the options for each image. Some do give over-sharpening of some details. It can always be masked out if you do denoise on a new layer.
I’m an athiest when it comes to sharpening – it can be done at the pixel level, enough to compensate for the anti-aliasing softening when the Bayer sensor pattern of the raw file is translated to pixels, but beyond that it is mostly has to be done by introducing artifacts. Sometimes it can improve things a bit, but check at 100%. The Sharpening slider in LR can compensate for antialiasing, and it is set at a default of 25 to do that, approximately. Some images can take a higher setting. The Texture slider will do a somewhat broader scale pseudo-sharpening. The high pass filter method is about the best for larger-scale sharpening.
But I will confess I haven’t used the Topaz Sharpen thing much, and since I paid for it I should give it a better try. But Topaz DeNoise is worth whatever I have ever paid for any and all Topaz products.